Cats: 1

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Spycher M, Bauer A, Jagannathan V, Frizzi M, De Lucia M, Leeb T. A frameshift variant in the COL5A1 gene in a cat with Ehlers-Danlos syndrome. Anim Genet. 2018;49(6):641–4. Epub 2018/09/25. pmid:30246406. Yu Y, Shumway KL, Matheson JS, Edwards ME, Kline TL, Lyons LA. Kidney and cystic volume imaging for disease presentation and progression in the cat autosomal dominant polycystic kidney disease large animal model. BMC Nephrology. 2019;20(1):259. pmid:31299928 Hengel H, Bosso-Lefevre C, Grady G, Szenker-Ravi E, Li H, Pierce S, et al. Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy. Nat Commun. 2020;11(1):595. Epub 2020/02/01. pmid:32001716; PubMed Central PMCID: PMC6992768. Yu Y, Grahn RA, Lyons LA. Mocha tyrosinase variant: a new flavour of cat coat coloration. Anim Genet. 2019;50(2):182–6. Epub 2019/02/05. pmid:30716167.

Lodge, Guy (19 July 2019). "Litter-ally terrifying: is Cats the creepiest film of the year?". The Guardian. ISSN 0261-3077. Archived from the original on 19 July 2019 . Retrieved 19 July 2019. Fire the Cat Cannon to blast baddies getting too close to your base! Overcome weird enemies with the right Cat squad and take down the enemy base!David Rooney of The Hollywood Reporter felt that the film was "hobbled by a major misjudgment in its central visual concept", lamenting its execution (such as the poor proportions of the "cats" to their environments) and deeming the film "exhausting". [88] Peter Travers of Rolling Stone rated the film zero stars out of five, stating it was "bizarre", had terrible special effects, and made the audience "want to cry for mercy", while Hooper "traps the actors in an airless, lifeless bubble of a film that scarcely gives them room to breathe, much less develop a character". [89] Lang, Brent (6 October 2021). "Andrew Lloyd Webber on Broadway's Reopening, 'Cinderella' and Why the 'Cats' Movie Caused Him to Buy a Dog". Variety . Retrieved 7 October 2021. Competing interests: The authors disclose there are no conflicts of interest. The funders had no role in study design, data collection, data analysis, interpretation of results, or decision to publish. D'Alessandro, Anthony (16 October 2018). " 'Cats': Idris Elba Boarding Universal-Working Title Movie As Macavity". Deadline. Archived from the original on 17 October 2018 . Retrieved 21 February 2019.

Domestic cats, while a great source of comfort to millions, are the largest carriers of toxoplasmosis that cause zoonosis, a study published in Nature Communications shows.Horton WA, Hall JG, Hecht JT. Achondroplasia. Lancet. 2007;370(9582):162–72. Epub 2007/07/17. pmid:17630040. Daetwyler HD, Capitan A, Pausch H, Stothard P, van Binsbergen R, Brondum RF, et al. Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle. Nat Genet. 2014;46(8):858–65. Epub 2014/07/16. pmid:25017103.

Kilday, Gregg (8 January 2019). "Dorian Awards: The Favourite Named Film of the Year". The Hollywood Reporter . Retrieved 8 January 2019. Fallon, Kevin (18 July 2019). "The 'Cats' Trailer, With Taylor Swift and Jennifer Hudson, Has Shaken Me to My Core". The Daily Beast . Retrieved 17 July 2019. D'Alessandro, Anthony (25 September 2018). " 'Cats' Cast Grows: Tom Hooper-Directed Musical Adds Laurie Davidson". Archived from the original on 26 September 2018 . Retrieved 25 September 2018. Rausch T, Zichner T, Schlattl A, Stutz AM, Benes V, Korbel JO. DELLY: structural variant discovery by integrated paired-end and split-read analysis. Bioinformatics. 2012;28(18):i333–i9. pmid:22962449; PubMed Central PMCID: PMC3436805. Xue C, Raveendran M, Harris RA, Fawcett GL, Liu X, White S, et al. The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences. Genome Res. 2016;26(12):1651–62. Epub 2016/12/10. pmid:27934697; PubMed Central PMCID: PMC5131817.

Background

Cats was released digitally on 17 March 2020, and on Blu-ray Disc and DVD on 7 April in the United States. The film was released on 29 April 2020 in Australia and on 1 June 2020 in the United Kingdom. D'Alessandro, Anthony (25 September 2018). " 'Cats' Cast Grows: Tom Hooper-Directed Musical Adds Laurie Davidson". Deadline. Archived from the original on 26 September 2018 . Retrieved 21 February 2019. In September 2018, Laurie Davidson and Mette Towley were cast, with Steven Spielberg announced to be executive producing. [39] [40] In October 2018, Idris Elba and Judi Dench joined the cast of the film. [41] [42] Dench was cast in the original stage musical, but had been forced to pull out due to a torn Achilles tendon; Lloyd Webber and Hooper decided to make Old Deuteronomy a female cat and offered her the role. [43] Simran Hans of The Observer agreed that "many of its uncanny images are sure to haunt viewers for generations". Her one-star review described the film as "a clear career low" for most of the actors, wondering whether they "are aware of what they've gotten themselves into". [62] Peter Bradshaw for The Guardian agreed with the one-star rating. In a review parodying " The Naming of Cats", he criticised the visual style and particularly the character design, while lambasting the film as a "dreadful hairball of woe". [91] Masso, Giverny (16 April 2019). "Naoimh Morgan: 'Acting in the Cats movie is a dream come true' | Interviews". Archived from the original on 16 April 2019 . Retrieved 16 April 2019.

Ross, Daniel. "5 reasons why Jennifer Hudson's version of 'Memory' is the best thing about the new Cats movie". Classic FM. Archived from the original on 31 December 2019 . Retrieved 2 January 2020. Tartaglione, Nancy (24 November 2018). " 'Cats': 'Hamilton' Tony Winner Andy Blankenbuehler To Choreograph Universal-Working Title Film". Deadline. Archived from the original on 24 November 2018 . Retrieved 21 February 2019. Most of the Jellicle Ball competitors are introduced and sing about themselves: Jennyanydots, a domestic tabby who sleeps during the day and by night boosts the productivity of mice and roaches; the Rum Tum Tugger, an extravagant yet indecisive cat who riles up the others; Bustopher Jones, a bourgeois cat who boasts about his weight and shares food scraps from the garbage; Skimbleshanks, a tidy ginger cat who tap dances and supervises the operation of a train, and Gus, an aged theatrical cat who has played some of the biggest roles in history. To the left of the figure panels, constraint groups are labeled with pLI ranges shown below in braces. Below the pLI ranges are the number of genes found in each constraint group. SNV values show the total number of SNVs of a particular impact that belong to each constraint group. (a) Observed percentage differences from expected values for per kb SNV density. Light colored rectangles represent the 95% confidence intervals for the expected values. Confidence intervals were calculated using 10,000 permutations (methods). (b) The percentage of SNVs of different impacts and constraint groups across various MAF intervals. (c) Observed percentage differences from expected values for the fraction of SNVs in a singleton state (allele count of 1). Light colored rectangles represent the 95% confidence intervals for the expected values, generated from 10,000 permutations. (d) Pairwise SNV count contrasts between gene constraint groups and SNVs of the same impact. “*” indicates a p-value < 0.05 and “**” indicates a p-value < 0.001. (e) Pairwise singleton count contrasts between gene constraint groups and SNVs of the same impact. Asterisks above odds ratio values indicate the same values as (d).

Figures

Pontius JU, Mullikin JC, Smith DR, Agencourt Sequencing T, Lindblad-Toh K, Gnerre S, et al. Initial sequence and comparative analysis of the cat genome. Genome Res. 2007;17(11):1675–89. Epub 2007/11/03. pmid:17975172; PubMed Central PMCID: PMC2045150.